Nemo is the largest science museum in the Netherlands. The building, designed in 1997 by star architect Renzo Piano, stands on the foundations of the IJ tunnel in the Oosterdok. It forms the entrance to the tunnel and is reminiscent of the hull of a ship. The roof is a popular meeting and viewing point. Generally, the roof is also open to non-visitors. Picnics are expressly permitted.

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​The science center opened in 1997 under the name "New Metropolis" and was renamed in 2000 after financial problems had appeared. Around 300,000 visitors visit Nemo each year. The science centre contains exhibits from all areas of science on four levels. The focus is on hands-on experiments and technical and biological education for children.